• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Heterocyclic oxyacetic acid diuretics: indazole, benzisothiazole, and benzisothiazole 1,1-dioxide analogues of [[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy]acetic acid.

作者信息

Shutske G M, Allen R C, Försch M F, Setescak L L, Wilker J C

出版信息

J Med Chem. 1983 Sep;26(9):1307-11. doi: 10.1021/jm00363a016.

DOI:10.1021/jm00363a016
PMID:6887205
Abstract

The indazole, benzisothiazole, and benzisothiazole 1,1-dioxide analogues of [[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy]acetic acid were synthesized and tested for diuretic activity in saline-loaded mice. Each analogue was found to be less active than the parent benzisoxazole: the diuretic activity followed the order O greater than S greater than N = SO2 in regard to the heteroatom in the 1-position of the ring.

摘要

相似文献

1
Heterocyclic oxyacetic acid diuretics: indazole, benzisothiazole, and benzisothiazole 1,1-dioxide analogues of [[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy]acetic acid.
J Med Chem. 1983 Sep;26(9):1307-11. doi: 10.1021/jm00363a016.
2
[(3-aryl-1,2-benzisoxazol-6-yl)oxy]acetic acids. A new diuretic series.
J Med Chem. 1982 Jan;25(1):36-44. doi: 10.1021/jm00343a008.
3
Substituted 5,6-dihydrofuro[3,2-f]-1,2-benzisoxazole-6-carboxylic acids: high-ceiling diuretics with uricosuric activity.
J Med Chem. 1984 Aug;27(8):1016-26. doi: 10.1021/jm00374a014.
4
[(6,7-Dichlorobenzo[b]thien-5-yl)oxy]acetic acids and 1,1-dioxides. 1. A structurally novel class of diuretics with hypotensive activity.[(6,7-二氯苯并[b]噻吩-5-基)氧基]乙酸及其1,1-二氧化物。1. 一类具有降压活性的结构新颖的利尿剂。
J Med Chem. 1987 Dec;30(12):2295-303. doi: 10.1021/jm00395a020.
5
(Acylaryloxy)acetic acid diuretics. 2. (2-Alkyl-2-aryl-1-oxo-5-indanyloxy)acetic acids.
J Med Chem. 1978 May;21(5):437-43. doi: 10.1021/jm00203a006.
6
Synthesis and diuretic profile of 3-(3-amino-1,2,4-oxadiazol-5-yl)-5-chloro-2,6-pyrazinediamine, an amiloride-type diuretic.3-(3-氨基-1,2,4-恶二唑-5-基)-5-氯-2,6-吡嗪二胺（一种氨氯吡脒类利尿剂）的合成及利尿特性
J Med Chem. 1980 Jun;23(6):690-2. doi: 10.1021/jm00180a025.
7
(Vinylaryloxy)acetic acids. A new class of diuretic agents. 3. ((2-Nitro-1-alkenyl)aryloxy)acetic acids.
J Med Chem. 1976 Jun;19(6):783-7. doi: 10.1021/jm00228a009.
8
Studies on uricosuric diuretics. III. Substituted 1,3-dioxolo[4,5-f]-1,2-benzisoxazole-6-carboxylic acids and 1,3-dioxolo[4,5-g]-1,2-benzisoxazole-7-carboxylic acids.
Chem Pharm Bull (Tokyo). 1992 Jan;40(1):109-16. doi: 10.1248/cpb.40.109.
9
The structure of (1,2-benzisoxazol-3-yl)methanesulfonamide: a novel antiepileptic drug.（1,2-苯并异恶唑-3-基）甲磺酰胺的结构：一种新型抗癫痫药物。
Acta Crystallogr C. 1988 Nov 15;44 ( Pt 11):2013-6. doi: 10.1107/s0108270188008704.
10
(Vinylaryloxy)acetic acids. A new class of diuretic agents. 2. (4-(3-Oxo-1-alkenyl)phenoxy)acetic acids.
J Med Chem. 1976 Apr;19(4):544-7. doi: 10.1021/jm00226a020.

引用本文的文献

1
(Z)-3-Chloro-methyl-idene-5,6-dimeth-oxy-2-methyl-2,3-dihydro-1,2-benzothia-zole 1,1-dioxide.
Acta Crystallogr Sect E Struct Rep Online. 2010 Dec 4;67(Pt 1):o12. doi: 10.1107/S1600536810049561.