Gould S A, Sehgal L R, Rosen A L, Langdale L A, Sehgal H L, Krause L, Moss G S
J Trauma. 1983 Aug;23(8):720-4. doi: 10.1097/00005373-198308000-00007.
We have previously reported on the efficacy of a 20% fluorocarbon emulsion (Fluosol-DA, 20%) as an acellular O2 carrier at an FIO2 = 1.0. We are concerned, however, about the potential O2 toxicity that may result from extended exposure to FIO2 = 1.0. The O2 content of the fluorocarbon phase is linearly related to both the FIO2 and the fluorocarbon concentration (Fct). It should therefore be possible to maintain the same O2 content by raising the Fct using a higher fluorocarbon concentration and lowering the FIO2. The purpose of this report is to assess the ability of a 35% fluorocarbon emulsion (Fluosol-DA, 35%) at an FIO2 = 0.6 to support hemodynamics and O2 transport. Five adult baboons were paralyzed, anesthetized, intubated, and mechanically ventilated at FIO2 = 0.6. An isovolemic total exchange transfusion (E.T.) with Fluosol-DA, 35% was performed. Measurements were made at Hct's of 20, 10, 5, and less than 2%. All animals survived the exchange. Total arterial O2 content fell from 17.4 +/- 0.7 to 3.3 +/- 0.2 vol% (p less than 0.01), and O2 delivery decreased from 21.8 +/- 2.2 to 5.1 +/- 0.7 cc/min-kg (p less than 0.01) during the exchange. There was no significant change in MAP, H.R., C.O., or VO2 during the exchange transfusion. Fluosol-DA, 35% maintains normal hemodynamics and O2 transport despite a marked fall in arterial O2 content and total O2 delivery. Fluosol-DA, 35% is thus an effective O2 carrier at the safe FIO2 of 0.6.
我们之前曾报道过20%氟碳乳剂（Fluosol-DA，20%）作为无细胞氧载体在吸入氧分数（FIO2）=1.0时的疗效。然而，我们担心长时间暴露于FIO2 = 1.0可能会导致潜在的氧中毒。氟碳相中的氧含量与FIO2和氟碳浓度（Fct）均呈线性相关。因此，通过使用更高的氟碳浓度提高Fct并降低FIO2，应该有可能维持相同的氧含量。本报告的目的是评估35%氟碳乳剂（Fluosol-DA，35%）在FIO2 = 0.6时支持血流动力学和氧运输的能力。五只成年狒狒被麻痹、麻醉、插管，并在FIO2 = 0.6下进行机械通气。用35%的Fluosol-DA进行等容全血交换输血（E.T.）。在血细胞比容（Hct）为20%、10%、5%和低于2%时进行测量。所有动物在交换过程中均存活。在交换过程中，总动脉氧含量从17.4±0.7降至3.3±0.2容积%（p<0.01），氧输送从21.8±2.2降至5.1±0.7毫升/分钟-千克（p<0.01）。在交换输血过程中，平均动脉压（MAP）、心率（H.R.）、心输出量（C.O.）或氧耗量（VO2）无显著变化。尽管动脉氧含量和总氧输送显著下降，但35%的Fluosol-DA仍能维持正常的血流动力学和氧运输。因此，35%的Fluosol-DA在安全的FIO2为0.6时是一种有效的氧载体。
