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Effect of gut lavage on phenobarbital elimination in rats.

作者信息

Lenz K, Mõrz R, Kleinberger G, Pointner H, Druml W, Laggner A

出版信息

J Toxicol Clin Toxicol. 1983 Apr;20(2):147-57. doi: 10.3109/15563658308990059.

DOI:10.3109/15563658308990059
PMID:6887307
Abstract

In the management of intoxications, the major goals are enhanced elimination of the toxin from the organism and prevention of further absorption. Absorption of an orally administered substance from the gastrointestinal tract can be decreased by adequate washing of the stomach. Delayed absorption of the substance from the small intestine cannot be avoided by this procedure and after the gastric lavage, a nonspecific absorbent must be administered and diarrhea induced (1). This study demonstrates that iatrogenic diarrhea via gut lavage can also eliminate toxins already absorbed by the body.

摘要

相似文献

1
Effect of gut lavage on phenobarbital elimination in rats.
J Toxicol Clin Toxicol. 1983 Apr;20(2):147-57. doi: 10.3109/15563658308990059.
2
Transport of phenobarbitone into the intestinal lumen and the biliary tract following i.v. administration to rats.静脉注射给予大鼠苯巴比妥后其在肠腔和胆道中的转运。
J Pharm Pharmacol. 1986 May;38(5):391-3. doi: 10.1111/j.2042-7158.1986.tb04595.x.
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Accelerated clearance of intravenously administered theophylline and phenobarbital by oral doses of activated charcoal in rats. A possibility of the intestinal dialysis.口服活性炭加速大鼠静脉注射氨茶碱和苯巴比妥的清除。肠道透析的可能性。
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Inhibition of glutethimide absorption.
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引用本文的文献

1
Controlled release drugs in overdose. Clinical considerations.过量服用的控释药物。临床考量。
Drug Saf. 1995 Jan;12(1):73-84. doi: 10.2165/00002018-199512010-00006.
2
Role of repeated oral doses of activated charcoal in clinical toxicology.重复口服活性炭在临床毒理学中的作用。
Med Toxicol. 1986 Jan-Feb;1(1):3-11. doi: 10.1007/BF03259824.
3
Whole bowel irrigation as a gastrointestinal decontamination procedure after acute poisoning.全肠道灌洗作为急性中毒后的胃肠道去污程序。
Med Toxicol Adverse Drug Exp. 1988 Mar-Apr;3(2):77-84. doi: 10.1007/BF03259934.