Kowalczyk D F, Beech J
J Vet Pharmacol Ther. 1983 Jun;6(2):133-40. doi: 10.1111/j.1365-2885.1983.tb00390.x.
The pharmacokinetics of the anti-convulsant phenytoin were investigated in clinically healthy horses after oral (p.o.) and intravenous (i.v.) administration. A single dose of phenytoin (8.8 mg/kg body weight) was given i.v. as a bolus to nine horses and one horse received 13.2 mg/kg. A two-compartment open model was used to describe the disposition of phenytoin. Four of the horses that received an i.v. dose (three at 8.8 mg/kg and one at 13.2 mg/kg) were then given the same dose 3 days later by the oral route. Phenytoin achieved a peak concentration in serum within 1-4 h after p.o. administration and was poorly absorbed with a bioavailability of 34.5 +/- 8.6%. Oral dosage regimens were calculated on the basis of a dosing interval of 8 h to provide average serum steady-state concentrations of 5 and 10 micrograms/ml for phenytoin.
在临床健康马匹经口服（p.o.）和静脉注射（i.v.）给药后，研究了抗惊厥药物苯妥英的药代动力学。以静脉推注方式给9匹马静脉注射单剂量苯妥英（8.8毫克/千克体重），1匹马接受13.2毫克/千克剂量。采用二室开放模型描述苯妥英的处置情况。然后，给4匹接受静脉注射剂量的马（3匹接受8.8毫克/千克剂量，1匹接受13.2毫克/千克剂量）在3天后经口服途径给予相同剂量。苯妥英口服给药后1 - 4小时内在血清中达到峰值浓度，吸收较差，生物利用度为34.5±8.6%。基于8小时的给药间隔计算口服给药方案，以使苯妥英的平均血清稳态浓度达到5和10微克/毫升。
