Eckstein B
J Steroid Biochem. 1983 Jul;19(1C):883-6. doi: 10.1016/0022-4731(83)90028-6.
Androstanediols are the major products of the immature rat ovary. About two-thirds are present in blood as sulfates. One of the sulfate conjugates was identified as 5 alpha-androstane-3 beta,17 beta-diol-3-monosulfate. This steroid effectively inhibits postcastrational LH elevation in a concentration in which it is present in blood. Other androstanediol sulfates examined were without this activity. In the immature rat, levels of 3 alpha- and 3 beta-diol decrease sharply before the first ovulation. In Wistar rats, PMSG-treatment induced a similar decline in these steroids. When ovulation in PMSG-treated rats was blocked by pentobarbitone, the LH-surge and the decline of the 3 alpha- and 3 beta-diols was delayed. Thus, it seems that the decline in the blood concentration of the diols depends on the first LH surge.
雄烷二醇是未成熟大鼠卵巢的主要产物。约三分之二以硫酸盐形式存在于血液中。其中一种硫酸酯结合物被鉴定为5α-雄烷-3β,17β-二醇-3-单硫酸盐。这种甾体在血液中存在的浓度下能有效抑制去势后促黄体生成素（LH）的升高。所检测的其他雄烷二醇硫酸盐没有这种活性。在未成熟大鼠中，3α-二醇和3β-二醇的水平在首次排卵前急剧下降。在Wistar大鼠中，孕马血清促性腺激素（PMSG）处理导致这些甾体出现类似下降。当用戊巴比妥阻断PMSG处理大鼠的排卵时，LH峰以及3α-二醇和3β-二醇的下降被延迟。因此，二醇血液浓度的下降似乎取决于首次LH峰。
