Nb rat prostate adenocarcinoma model androgen-sensitive tumor: metastasis control.

In this preliminary report, evaluation of nontraditional agents has been used to evaluate control of metastasis. This androgen-sensitive rate prostatic adenocarcinoma has been subject to the treatments of heparin, indocin, and castration, as well as combinations of castration, heparin, indocin, and cyclophosphamide. Tumor volume, metastasis, and determination of regression of primary tumor have been evaluated. Heparin and indocin both reduced metastasis without affecting tumor volume in this study. The combination of castration and cyclophosphamide was most effective in reducing tumor volume when compared to the other groups.