大鼠肝脏中柔红霉素结合蛋白的纯化及部分特性鉴定
Purification and partial characterization of a daunorubicin-binding protein from rat liver.
作者信息
Gambetta R A, Colombo A, Lanzi C, Zunino F
出版信息
Mol Pharmacol. 1983 Sep;24(2):336-40.
PMID:6888375
Abstract
A daunorubicin-binding protein has been isolated from the soluble fraction of normal rat liver by affinity chromatography on daunorubicin-Sepharose columns. This protein, which apparently binds anthracyclines specifically, appears to be composed of four polypeptides of 54,000 Mr, is different from tubulin, and is not involved in anthracycline metabolism. Its physiological function remains to be determined.
摘要
通过柔红霉素-琼脂糖柱亲和层析法，从正常大鼠肝脏的可溶部分分离出一种柔红霉素结合蛋白。这种蛋白显然能特异性结合蒽环类药物，似乎由四个分子量为54,000的多肽组成，与微管蛋白不同，且不参与蒽环类药物的代谢。其生理功能尚待确定。
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