Bourne G W, Théorêt Y, Esplin B, Capek R
Naunyn Schmiedebergs Arch Pharmacol. 1983 Jun;323(2):168-72. doi: 10.1007/BF00634266.
The effects of phencyclidine (PCP) on synaptic transmission were studied in the hippocampal slice. Population spikes evoked by orthodromic or antidromic stimulation were recorded from CAl pyramidal cells. Bath applied PCP (10(-4) M) reduced moderately both the orthodromic and antidromic population spikes. Lower concentrations, 5 X 10(-6) to 5 X 10(-5) M of PCP, which did not depress the population spikes, reduced inhibition of the orthodromically evoked spike in a dose dependent reversible manner. Diazepam (10(-6) to 10(-5) M) restored the inhibition despite the continued presence of PCP. It is suggested that PCP-induced seizures and other signs of hyperexcitability could be a result of reduced inhibition.
在海马切片中研究了苯环己哌啶（PCP）对突触传递的影响。从CA1锥体细胞记录由顺向或逆向刺激诱发的群体峰电位。浴加PCP（10⁻⁴M）适度降低了顺向和逆向群体峰电位。较低浓度（5×10⁻⁶至5×10⁻⁵M）的PCP虽不抑制群体峰电位，但以剂量依赖性可逆方式降低了对顺向诱发峰电位的抑制作用。尽管PCP持续存在，但地西泮（10⁻⁶至10⁻⁵M）恢复了抑制作用。提示PCP诱发的癫痫发作和其他过度兴奋的体征可能是抑制作用降低的结果。
