Robinson B F
Postgrad Med J. 1983;59 Suppl 2:104-8.
Local infusion of verapamil induced a significantly greater dilatation in the forearm resistance vessels of men with primary hypertension than that observed in a control group of men with normal arterial pressure; the response to sodium nitroprusside, however, was reduced. These findings indicate an abnormality in the mechanisms by which resistance vessel tone is maintained in patients with raised arterial pressure and they suggest that calcium channel blockers may be particularly suited for use as arteriolar dilators in hypertension. In an open trial in patients with hypertension that was inadequately controlled by the combination of a beta-adrenoceptor antagonist and a diuretic, nifedipine was shown to be effective in causing a further fall in arterial pressure; this finding was confirmed in a subsequent double-blind, placebo controlled study.
对原发性高血压男性患者的前臂阻力血管进行维拉帕米局部输注，其引起的血管扩张程度显著大于动脉血压正常的男性对照组；然而，硝普钠的反应则有所降低。这些发现表明，动脉血压升高患者中维持阻力血管张力的机制存在异常，提示钙通道阻滞剂可能特别适合用作高血压患者的小动脉扩张剂。在一项针对高血压患者的开放试验中，β-肾上腺素能受体拮抗剂和利尿剂联合治疗控制不佳，硝苯地平被证明可有效使动脉血压进一步下降；这一发现随后在一项双盲、安慰剂对照研究中得到证实。
