铯可减弱大鼠和小鼠的条件性回避反应。

Cesium attenuates conditioned avoidance response in rats and mice.

作者信息

Bose R, Pinsky C

出版信息

Pharmacol Biochem Behav. 1983 Jun;18(6):867-71. doi: 10.1016/s0091-3057(83)80007-0.

Abstract

The pole-climbing conditioned avoidance response (CAR) was attenuated in rats after four once-daily injections of CsCl intraperitoneally at 3.0 mEq kg-1 and in mice after seven such injections at 5.0 mEq kg-1. Suppression of CAR increased with increasing numbers of injections. Treatment with cesium did not attenuate the unconditioned pole-climbing escape response to mild footshock. The cesium effect on CAR resembles that of antidopaminergic phenothiazine like agents, in concordance with our earlier studies which showed cesium potentiation of pentobarbital sleeping time and antagonism of amphetamine toxicity.

摘要

在大鼠中，每天腹腔注射一次3.0 mEq kg-1的CsCl，共注射四次后，其爬杆条件性回避反应（CAR）减弱；在小鼠中，每天腹腔注射一次5.0 mEq kg-1的CsCl，共注射七次后，其CAR减弱。随着注射次数的增加，CAR的抑制作用增强。铯处理并未减弱对轻度足部电击的非条件性爬杆逃避反应。铯对CAR的作用类似于抗多巴胺能吩噻嗪类药物的作用，这与我们早期的研究结果一致，早期研究表明铯可增强戊巴比妥睡眠时间并拮抗苯丙胺毒性。