Banfi S, Fonio W, Allievi E, Raimondo S
Pharmacol Res Commun. 1983 May;15(5):553-8. doi: 10.1016/s0031-6989(83)80072-1.
Rats were rendered epileptic by subpial injection of an FeCl3 solution. Epileptiform discharges, recorded by chronically implanted extradural electrodes, were evident within 48 h of surgery and persisted for more than 6 months. It is demonstrated that this model is useful for studying new antiepileptic agents since a series of clinically effective drugs (diazepam, clonazepam, Na phenobarbital, primidone, carbamezepine, ethosuximide, diphenylhydantoin, Na valproate, GABOB) show an activity which is does-dependent and within a range satisfactorily related to human dosages.
通过在软脑膜下注射氯化铁溶液使大鼠诱发癫痫。通过长期植入硬膜外电极记录的癫痫样放电在手术48小时内明显出现，并持续超过6个月。结果表明，该模型对于研究新型抗癫痫药物是有用的，因为一系列临床有效的药物（地西泮、氯硝西泮、苯巴比妥钠、扑米酮、卡马西平、乙琥胺、苯妥英钠、丙戊酸钠、γ-氨基丁酸）显示出剂量依赖性活性，且在与人体剂量有令人满意相关性的范围内。
