Schilsky R L, Barlock A, Ozols R F
Cancer Treat Rep. 1982 Sep;66(9):1767-9.
Twenty-nine patients with nonseminomatous germ cell tumors of the testis have been followed for a median of 1.9 years (range 0.3-3.6) following completion of cisplatin-containing combination chemotherapy. Twenty-two of the 29 patients (76%) became hypomagnesemic during chemotherapy and, of these, 11 (50%) have remained persistently hypomagnesemic for as long as 3 years following discontinuation of cisplatin treatment. In the remaining patients, serum Mg levels returned to normal a median of 0.6 years (range, 0.2-2.1) after completion of chemotherapy. In eight of nine persistently hypomagnesemic patients studied, urinary Mg excretion was inappropriately elevated. Symptoms attributable to hypomagnesemia were rarely reported, although muscle cramps, twitching, or mild tremor were noted by the most severely hypomagnesemic patients. Continued followup of these patients is required to determine the effects of chronic hypomagnesemia in man.
29例睾丸非精原细胞瘤患者在含顺铂联合化疗结束后接受了中位时间为1.9年（范围0.3 - 3.6年）的随访。29例患者中有22例（76%）在化疗期间出现低镁血症，其中11例（50%）在停用顺铂治疗后长达3年持续存在低镁血症。其余患者血清镁水平在化疗结束后中位0.6年（范围0.2 - 2.1年）恢复正常。在研究的9例持续低镁血症患者中，有8例尿镁排泄异常升高。尽管最严重低镁血症患者出现了肌肉痉挛、抽搐或轻度震颤，但很少有低镁血症相关症状的报告。需要对这些患者继续进行随访，以确定慢性低镁血症对人体的影响。
