Brinckmeyer L M, Skovsgaard T, Thiede T, Vesterager L, Nissen N I
Eur J Cancer Clin Oncol. 1982 May;18(5):421-8. doi: 10.1016/0277-5379(82)90109-2.
A retrospective analysis of staging results from 308 patients with Hodgkin's disease (HD) was performed in order to relate clinico-pathological findings with respect to the liver to other staging results and to prognosis. Thirty-four patients had clinically enlarged liver, 80 had increased serum-enzyme levels indicating possible liver damage, but only 10 patients had biopsy-proven histologic evidence of HD in the liver (7 primary biopsies, 3 re-biopsies). Among the prognostic correlations not only advanced stage and liver infiltrates were connected to poor prognosis, but also--even in early stages--elevated serum enzyme values (S-GOT and alkaline phosphate).
为了将肝脏的临床病理结果与其他分期结果及预后相关联，对308例霍奇金淋巴瘤（HD）患者的分期结果进行了回顾性分析。34例患者临床上肝脏肿大，80例患者血清酶水平升高提示可能存在肝损伤，但只有10例患者经活检证实肝脏有HD组织学证据（7例初次活检，3例再次活检）。在预后相关性方面，不仅晚期和肝脏浸润与预后不良相关，而且即使在早期，血清酶值（谷草转氨酶和碱性磷酸酶）升高也与预后不良相关。
