Pau M Y, Milner J A
J Nutr. 1982 Oct;112(10):1834-42. doi: 10.1093/jn/112.10.1834.
The effects of dietary arginine deficiency on sexual maturation were examined in the female rat. Consumption of a diet devoid of arginine since weaning delayed the onset of puberty. Weight at vaginal opening and weight at first estrus were significantly greater in the arginine-deficient rat than in the control rat. Arginine deficiency appeared to have a specific effect on the development of reproductive function since puberty in arginine-deficient animals was delayed more than could be accounted for by impairment of growth. The specific effect of arginine deficiency was also indicated by reduced weights of the reproductive tissues after 15 weeks of experimental feeding when compared with the growth-matched controls. Sexual maturation was also examined in rats fed diets containing graded levels of arginine (1.12, 0.84, 0.56, 0.28 or 0%). Vaginal opening and first estrus were delayed by feeding diets containing 0.28 or 0% arginine. Uncoupling of these two events also occurred in the majority of the rats fed these two diets. In spite of normal timing of puberty, maturing rats fed a diet with 0.56 of 0.84% arginine had reduced ovarian weight and first ovulation rate when compared with rats fed the control diet (1.12% arginine). It is concluded that more than 0.84% dietary arginine was required for growing rats to support normal sexual maturation.
在雌性大鼠中研究了饮食中精氨酸缺乏对性成熟的影响。自断奶起食用缺乏精氨酸的饮食会延迟青春期的开始。精氨酸缺乏的大鼠阴道口处的体重和首次发情时的体重显著高于对照大鼠。精氨酸缺乏似乎对生殖功能的发育有特定影响，因为精氨酸缺乏动物的青春期延迟程度超过了生长受损所能解释的范围。与生长匹配的对照组相比，实验喂养15周后，生殖组织重量减轻也表明了精氨酸缺乏的特定影响。还对喂食含不同精氨酸水平（1.12%、0.84%、0.56%、0.28%或0%）饮食的大鼠进行了性成熟研究。喂食含0.28%或0%精氨酸饮食会延迟阴道口张开和首次发情。喂食这两种饮食的大多数大鼠中这两个事件也出现了脱节。尽管青春期时间正常，但与喂食对照饮食（1.12%精氨酸）的大鼠相比，喂食含0.56%或0.84%精氨酸饮食的成熟大鼠卵巢重量和首次排卵率降低。得出的结论是，生长中的大鼠需要超过0.84%的饮食精氨酸来支持正常的性成熟。
