Jankovic J, Penn A S
Neurology. 1982 Oct;32(10):1195-7. doi: 10.1212/wnl.32.10.1195.
Myoglobinuria may follow extreme muscular exertion or disorders that cause muscle necrosis. Dystonia has not been implicated previously. We studied an 8-year-old boy of non-Jewish, Mexican-American descent with autosomal-dominant dystonia musculorum deformans who developed rapidly progressive and severe generalized dystonia, hyperpyrexia, myoglobinuria, and renal failure. Curarization was required. Transient improvement was achieved with tetrabenazine and baclofen, but bilateral thalamotomy was then performed. Patients with severe dystonia should be observed for evidence of myoglobinuria.
肌红蛋白尿可能继发于极度的肌肉劳累或导致肌肉坏死的疾病。肌张力障碍此前未被认为与之相关。我们研究了一名8岁非犹太裔墨西哥裔美国男孩，他患有常染色体显性遗传性变形性肌张力障碍，出现了快速进展的严重全身性肌张力障碍、高热、肌红蛋白尿和肾衰竭。需要进行箭毒化处理。使用丁苯那嗪和巴氯芬后病情暂时改善，但随后进行了双侧丘脑切开术。对于严重肌张力障碍患者，应观察是否有肌红蛋白尿的迹象。
