肾上腺皮质结构与功能的性别差异。IV. 青春期后性腺切除术和性激素对大鼠肾上腺类固醇5α-还原酶活性的影响。
Sex differences in adrenocortical structure and function. IV. Effects of postpubertal gonadectomy and sex hormones on adrenal steroid 5alpha-reductase activity in the rat.
作者信息
Malendowicz L K, Fichna P
出版信息
Endokrinologie. 1978 Apr;72(1):36-42.
Studies on the effects of gonadectomy and gonadal hormones on adrenal 5alpha-reductase activity in the rat were performed. In rats of both sexes postpubertal gonadectomy is followed by an increase in adrenal 5alpha-reductase activity. The enzyme activity gradually increases during 6 postoperative weeks. Replacement of testosterone or estradiol to gonadectomized rats within 5 days lowers the enzyme activity to the level observed in intact control rats. Likewise, testosterone injected to ovariectomized rats and estradiol administered to orchiectomized animals within 5 days reversed the effect of gonadectomy on 5alpha-reductase. In all experiments the temporal changes in 5alpha-reductase activity were similar. By contrast, the weight of seminal vesicles of gonadectomized rats was normalized after 7 days of testosterone action whereas the highest uterine weight was found 3 days post depot-estradiol injection. Regarding temporal changes in 5alpha-reductase activity the experiments revealed similar inhibitory action of testosterone and estradiol. This action probably depends on the inhibition of enzyme synthesis by gonadal hormones. Moreover, greater sensitivity of adrenals of gonadectomized rats to testosterone, if compared with seminal vesicles, was observed.
开展了关于性腺切除术和性腺激素对大鼠肾上腺5α-还原酶活性影响的研究。在青春期后的大鼠中，两性进行性腺切除术后，肾上腺5α-还原酶活性均会增加。术后6周内，该酶活性逐渐升高。在5天内向去势大鼠补充睾酮或雌二醇，可使酶活性降至完整对照大鼠所观察到的水平。同样，在5天内向卵巢切除大鼠注射睾酮以及向睾丸切除动物给予雌二醇，可逆转性腺切除术对5α-还原酶的影响。在所有实验中，5α-还原酶活性的时间变化相似。相比之下，去势大鼠的精囊重量在睾酮作用7天后恢复正常，而在注射长效雌二醇3天后发现子宫重量达到最高。关于5α-还原酶活性的时间变化，实验揭示了睾酮和雌二醇具有相似的抑制作用。这种作用可能取决于性腺激素对酶合成的抑制。此外，观察到与精囊相比，去势大鼠的肾上腺对睾酮更为敏感。
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