Quantitative structure-activity relationships. IV. Use of molecular negentropy as structural parameter.
作者信息
Gombar V K, Wadhwa L
出版信息
Arzneimittelforschung. 1982;32(7):715-8.
PMID:6889868
Abstract
Molecular negentropy, the measure of information content in a molecule, was found to be a useful parameter for quantitation of the structures of molecules eliciting some non-specific biological response. Quantitative correlations were obtained between negentropy of a variety of molecules and their 1. toxic effects on the Madison 517 fungus, 2. narcotic action on arenicola larvae, 3. inhibiting activity on tortoise heart and 4. narcotic effect of frog heart.
摘要
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