Effect of the immunomodulant 2-cyanaziridine derivative BM 41.332 on adjuvant arthritis in the rat.

2-Cyan-1-[(2-methoxy-6-methyl-pyridin-3-yl)-methyl]-aziridine (BM 41.332), a derivative of the immuno-stimulant group of 2-cyanaziridines, showed a therapeutic action in adjuvant arthritis in the rat. Although it does not possess any direct anti-inflammatory action, BM 41.332 showed activity which differed clearly from conventional antirheumatic agents such as cyclophosphamide, glucocorticoids, levamisole or indometacin.