Gedda L, Brenci G, Ziparo R
Boll Soc Ital Biol Sper. 1982 Jul 30;58(14):895-9.
In chronogenetic theory different genes have a different stability ("ergon") which determines the duration ("chronon") of their action. The ergon/chronon of each gene is considered to be inherited. In order to verify whether genomic stability is a heritable trait, the frequency of sister chromatid exchanges (SCE) was observed in a sample of 12 MZ twin pairs distributed as follows: (formula; see text) The minimum intrapair variability as against the high interpair variability as to mean S.C.E. counts supports the hypothesis of genetic control on S.C.E. frequency. The increase in S.C.E. frequency in older pairs indicates the age-dependence of the phenomenon. The study will be extended to both DZ pairs and older twin pairs.
在时间遗传学理论中,不同的基因具有不同的稳定性(“工作效率”),这决定了它们作用的持续时间(“时间子”)。每个基因的工作效率/时间子被认为是可遗传的。为了验证基因组稳定性是否是一种可遗传的性状,在12对同卵双胞胎样本中观察了姐妹染色单体交换(SCE)的频率,分布如下:(公式;见正文)平均S.C.E.计数方面,最小的双胞胎对内变异性与高双胞胎对间变异性支持了S.C.E.频率受遗传控制的假设。年龄较大的双胞胎对中S.C.E.频率的增加表明该现象具有年龄依赖性。该研究将扩展到异卵双胞胎对和年龄更大的双胞胎对。