小鼠逆行性遗忘中与衰老相关的变化。
Aging-related changes in retrograde amnesia for mice.
作者信息
Essman W B
出版信息
Gerontology. 1982;28(5):303-13. doi: 10.1159/000212547.
Aging mice showed a retrograde amnesia for passive avoidance behavior when a single electroconvulsive shock (ECS) was given at post-training intervals up to 1 h, whereas adult mice showed no significant amnesia when ECS was given 10 min or more after training. Catecholamines (norepinephrine and dopamine), but not serotonin (5-HT) changed with aging in the several brain regions, but only 5-HT was significantly changed (elevated) by ECS. Protein synthesis was significantly inhibited by ECS, notably in limbic structures. The increased susceptibility of aging mice to the amnesic effect of ECS could be related to aging-related changes in the rate of memory consolidation or to the duration of neural chemical changes that disrupt processes such as consolidation, storage, and/or retrieval of the memory trace.
衰老小鼠在训练后长达1小时的间隔内接受单次电休克（ECS）时，对被动回避行为表现出逆行性遗忘，而成年小鼠在训练后10分钟或更长时间接受ECS时则未表现出明显的遗忘。儿茶酚胺（去甲肾上腺素和多巴胺）而非血清素（5-HT）在几个脑区随衰老而变化，但只有5-HT因ECS而发生显著变化（升高）。ECS显著抑制蛋白质合成，尤其是在边缘结构中。衰老小鼠对ECS遗忘效应的易感性增加可能与记忆巩固速率的衰老相关变化有关，或者与破坏记忆痕迹的巩固、存储和/或检索等过程的神经化学变化持续时间有关。
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