在条件刺激-非条件刺激间隔期间通过电惊厥休克（ECS）给予破坏对饮用冷水的条件性厌恶的逆行梯度。

A retrograde gradient for disruption of a conditioned aversion to drinking cold water by ECS administered during the CS-US interval.

作者信息

Kasprow W J, Schachtman T R, Miller R R

出版信息

Physiol Behav. 1985 Jun;34(6):879-82. doi: 10.1016/0031-9384(85)90007-1.

Abstract

Rats were used to examine the effects, upon a conditioned aversion to cold drinking water, of electroconvulsive shock (ECS) delivered during the delay between cue and unconditioned stimulus. An injection of LiCl (US) 30 min after ingestion of novel cold water (CS) produced a reliable aversion to the cold water. ECS given immediately following the ingestion of cold water substantially attenuated this aversion. An orderly decrease in the attenuation of the aversion was observed when ECS was delayed 5, 10 or 20 min after offset of the cold water cue. The results indicate that ingestive cue aversions can be formed without electrochemical neural-transmission-based representation of the cue being maintained during the CS-US interval. The differential effectiveness of ECS suggests that this agent retroactively interferes with processing of the ingestive cue.

摘要

使用大鼠来研究在条件刺激与非条件刺激之间的延迟期间给予电惊厥休克（ECS）对冷饮用水条件性厌恶的影响。在摄入新奇冷水（条件刺激）30分钟后注射氯化锂（非条件刺激）会产生对冷水的可靠厌恶。在摄入冷水后立即给予ECS可显著减弱这种厌恶。当在冷水刺激消失后5、10或20分钟延迟给予ECS时，观察到厌恶减弱程度呈有序下降。结果表明，在条件刺激 - 非条件刺激间隔期间，无需基于电化学神经传递的刺激表征即可形成摄食性条件厌恶。ECS的不同效果表明该药剂会追溯性地干扰摄食性刺激的处理。