Kaltenbach F J
Fortschr Med. 1977 Jun 9;95(22):1450-5.
The alteration of the proliferation activity of different tissues of the female genital tract was studied with the histo-autoradiographic method. Tissue samples from 1. the normal endometrium before and under treatment with the sequential oral contraceptive Ovanon, 2. carcinomas of the vulva before and under treatment with Bleomycin, 3. cervical carcinomas stage I-III before and under Co 60-radiation, and fluid material of cystic ovarian tumors and effusions before and under treatment with alkylating agents were incubated in 3H-thymidine. Morphologic and histo-autoradiographic alterations were observed during all investigations. It was demonstrated that the histo-autoradiographic method 1. gives informations about the proliferation activity of tissues of the female genital tract, 2. quantifies the success of treatment, 3. and allows prognosis about therapeutic results, as it was shown in the case of radiation sensitivity of cervix carcinomas.
采用组织自显影法研究了女性生殖道不同组织增殖活性的改变。对以下组织样本进行了研究：1. 服用序贯口服避孕药奥凡农前后的正常子宫内膜；2. 注射博来霉素前后的外阴癌；3. I - III期宫颈癌在钴60放疗前后；以及囊性卵巢肿瘤和积液在使用烷化剂治疗前后的液体样本，将这些样本与3H - 胸腺嘧啶一起孵育。在所有研究过程中均观察到形态学和组织自显影的改变。结果表明，组织自显影法：1. 可提供有关女性生殖道组织增殖活性的信息；2. 能够量化治疗效果；3. 并可对治疗结果进行预后评估，这在宫颈癌的放射敏感性研究中得到了证实。
