Hirakawa K, Unno T, Ogino F, Takebe H, Iino T, Nose T
Arzneimittelforschung. 1982;32(9):1078-86.
Using male and female Beagles, we studied the subacute toxicity of diethyl 4-(benzothiazol-2-yl)benzylphosphonate (KB-944) administered orally and the following results were obtained. No dogs died during the administration period. Both male and female dogs given 200 mg/kg and those given 100 mg/kg underwent body weight decrease and inhibition of body weight increase, respectively. Enlargement of liver cells occurred in male dogs given 200 mg/kg and female dogs given 100 or 200 mg/kg. There were no further findings, even histopathologically, which showed any toxic effect of the drug. The maximum non-toxic dose of this drug was considered to be 30 mg/kg.
我们使用雄性和雌性比格犬，研究了口服4-(苯并噻唑-2-基)苄基膦酸二乙酯(KB-944)的亚急性毒性，获得了以下结果。给药期间无犬死亡。给予200mg/kg的雄性和雌性犬以及给予100mg/kg的犬分别出现体重下降和体重增加抑制。给予200mg/kg的雄性犬以及给予100mg/kg或200mg/kg的雌性犬出现肝细胞肿大。即使在组织病理学上，也没有进一步发现表明该药物有任何毒性作用。该药物的最大无毒剂量被认为是30mg/kg。
