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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Cruccu G, Bini G, Accornero N, Berardelli A, Manfredi M

Arzneimittelforschung. 1982;32(9):1146-9.

The effects of an orally administered single dose of placebo, acetylsalicyclic acid (ASA) and (d,1)-6-chloro-a-methyl carbazole-2-acetic acid (carprofen) have been evaluated on an experimental pain model by electrical stimulation of dental pulp in man. 2. ASA and carprofen showed a significant analgesic action, while placebo was ineffective. 3. Analgesic activity of ASA and carprofen was similar. The two drugs were ineffective in modifying the pain threshold; on the contrary, the tolerance to the strongest painful sensation was significantly increased.

通过对人类牙髓进行电刺激的实验性疼痛模型，评估了口服单剂量安慰剂、乙酰水杨酸（ASA）和（消旋）-6-氯-α-甲基咔唑-2-乙酸（卡洛芬）的效果。2. ASA和卡洛芬显示出显著的镇痛作用，而安慰剂无效。3. ASA和卡洛芬的镇痛活性相似。这两种药物在改变痛阈方面无效；相反，对最强疼痛感觉的耐受性显著增加。

Cruccu G, Bini G, Accornero N, Berardelli A, Manfredi M

Arzneimittelforschung. 1982;32(9):1146-9.

The effects of an orally administered single dose of placebo, acetylsalicyclic acid (ASA) and (d,1)-6-chloro-a-methyl carbazole-2-acetic acid (carprofen) have been evaluated on an experimental pain model by electrical stimulation of dental pulp in man. 2. ASA and carprofen showed a significant analgesic action, while placebo was ineffective. 3. Analgesic activity of ASA and carprofen was similar. The two drugs were ineffective in modifying the pain threshold; on the contrary, the tolerance to the strongest painful sensation was significantly increased.

通过对人类牙髓进行电刺激的实验性疼痛模型，评估了口服单剂量安慰剂、乙酰水杨酸（ASA）和（消旋）-6-氯-α-甲基咔唑-2-乙酸（卡洛芬）的效果。2. ASA和卡洛芬显示出显著的镇痛作用，而安慰剂无效。3. ASA和卡洛芬的镇痛活性相似。这两种药物在改变痛阈方面无效；相反，对最强疼痛感觉的耐受性显著增加。