Paulin F, Csömör S
Z Geburtshilfe Perinatol. 1982 Oct;186(5):244-8.
In a random controlled trial the effects of a betamimetic infusion (Fenoterol 2 micrograms/min) on the estriol excretion and the renal function were analysed in 30 patients in the 28.-34. weeks of pregnancy. It was stated that the estriol excretion in urine during the Partusisten infusion significant decreases (from 663 micrograms/2 h to 376 micrograms/2 h, i.e. to 56%). The diuresis and the creatinine-clearance showed a significant diminishing too (from 218 ml/2 h to 154 ml/2 h and from 131 ml/min to 88 ml/min). The decrease of estriol excretion is caused on the one hand by the diminution of GFR, on the other by a direct effect of betamimetics on the kidney. From the results obtained in this study the following consequences can be drawn: 1. The determination of urinary estriol during tocolytic treatment is not a suitable method for the monitoring the fetoplacental unit. 2. Applying the tocolysis in an infusion a possible reduction of water intake and a strict control of water balance is of great importance. 3. The betamimetic therapy in patients having an impaired renal function can be applied only with great precaution.
在一项随机对照试验中，对30例妊娠28至34周的患者分析了β - 拟交感神经药物输注（非诺特罗2微克/分钟）对雌三醇排泄和肾功能的影响。结果表明，在输注Partusisten期间，尿中雌三醇排泄量显著降低（从663微克/2小时降至376微克/2小时，即降至56%）。尿量和肌酐清除率也显著降低（从218毫升/2小时降至154毫升/2小时，从131毫升/分钟降至88毫升/分钟）。雌三醇排泄量的降低一方面是由于肾小球滤过率降低，另一方面是β - 拟交感神经药物对肾脏的直接作用。从本研究获得的结果可以得出以下结论：1. 在宫缩抑制治疗期间测定尿雌三醇不是监测胎儿 - 胎盘单位的合适方法。2. 在输注中应用宫缩抑制时，可能减少水的摄入并严格控制水平衡非常重要。3. 肾功能受损患者应用β - 拟交感神经药物治疗时必须极为谨慎。
