Falk H, Caldwell G G, Ishak K G, Thomas L B, Popper H
Am J Ind Med. 1981;2(1):43-50. doi: 10.1002/ajim.4700020108.
Data from several small autopsy series in German vintners in the 1940s and 1950s and a number of case reports have previously suggested that arsenic is a cause of hepatic angiosarcoma (HAS). In a nationwide review of deaths from HAS in the United States, we identified seven cases with a history of prolonged use of Fowler's solution (inorganic potassium arsenite), which provide further support for the association of arsenic exposure and HAS. An epidemiologic study of a cohort of individuals treated long-term with Fowler's solution might confirm this association.
20世纪40年代和50年代对德国酿酒工人进行的几个小型尸检系列的数据以及一些病例报告此前曾表明，砷是肝血管肉瘤（HAS）的一个病因。在美国对死于HAS的情况进行的一项全国性审查中，我们确定了7例有长期使用福勒溶液（无机亚砷酸钾）病史的病例，这为砷暴露与HAS之间的关联提供了进一步支持。对一组长期接受福勒溶液治疗的个体进行的流行病学研究可能会证实这种关联。
