Suzuki Y
Am J Ind Med. 1981;2(2):103-17. doi: 10.1002/ajim.4700020205.
Both subcutaneous and hepatic hemangiosarcomas were induced in mice exposed to vinyl chloride monomer, and for the first time, the ultrastructure of hemangiosarcomas related to vinyl chloride exposure has been described. The subcutaneous hemangiosarcoma developed in a mouse's ear 29 weeks after exposure to 10 ppm vinyl chloride for 4 weeks, and the hepatic hemangiosarcoma was found in a mouse's liver at necropsy 56 weeks after exposure to 600 ppm vinyl chloride for 4 weeks. Both tumors showed a localized, cystic nodular appearance with a dark red tone. Histologically, an angiomatous architecture, the presence of neoplastic mesenchymal cell aggregates, focal necrosis, and hemorrhagic foci were common. Ultrastructurally, two neoplastic cell types, a mesenchymal and a well-differentiated endothelial cell type, were identified in both tumors. In addition, in the hepatic tumor, a pericyte-like neoplastic cell was also present. The incidence of hemangiosarcoma was much lower than that of lung tumors (alveologenic tumor) in mice exposed to vinyl chloride at the same concentrations for the same duration. This study suggests that there is no basic difference in ultrastructure between the vinyl chloride-induced hemangiosarcomas and hemangiosarcomas not related to this chemical exposure.
在接触氯乙烯单体的小鼠中诱发了皮下和肝脏血管肉瘤，并且首次描述了与接触氯乙烯相关的血管肉瘤的超微结构。在接触10 ppm氯乙烯4周后29周，小鼠耳朵出现皮下血管肉瘤，在接触600 ppm氯乙烯4周后尸检时，在小鼠肝脏发现肝脏血管肉瘤。两种肿瘤均表现为局限性、囊性结节外观，呈暗红色。组织学上，血管性结构、肿瘤性间充质细胞聚集、局灶性坏死和出血灶很常见。超微结构上，在两种肿瘤中均鉴定出两种肿瘤细胞类型，一种是间充质细胞类型，另一种是分化良好的内皮细胞类型。此外，在肝脏肿瘤中还存在一种类周细胞肿瘤细胞。在相同浓度和相同持续时间接触氯乙烯的小鼠中，血管肉瘤的发生率远低于肺肿瘤（肺泡源性肿瘤）。这项研究表明，氯乙烯诱发的血管肉瘤与非该化学物质接触所致的血管肉瘤在超微结构上没有根本差异。
