苄基嘧啶的胰腺分泌。犬类实验研究。

Pancreatic secretion of benzylpyrimidines. Experimental studies in dogs.

作者信息

Vergin H, Bishop-Freudling G B, Merk K, Szelenyi I

出版信息

Arzneimittelforschung. 1982;32(10):1302-4.

Abstract

The high mortality of septicaemic complications in pancreatic diseases requires the prophylactic use of suitable antimicrobial agents. Thus, the pancreatic distribution of benzylpyrimidines has been studied in dogs. After injection of 5 mg/kg followed by constant infusion of 0.5 mg/kg/h, maximum concentrations of 3.88 +/- 1.46 micrograms/ml (metioprim, MTP), 6.07 +/- 4.95 micrograms/ml (trimethoprim, TMP) and 7.78 +/- 1.84 micrograms/ml (tetroxoprim, TXP) were reached in canine pancreatic secretion. With respect to plasma, the drugs show 2.72- (MTP), 3.57- (TMP) and 4.18fold (TXP) concentrations in pancreatic secretion as can be shown by calculation of the AUC-ratios.

摘要

胰腺疾病败血症并发症的高死亡率需要预防性使用合适的抗菌药物。因此，已在犬类中研究了苄基嘧啶在胰腺中的分布情况。注射5mg/kg后，以0.5mg/kg/h的速度持续输注，犬胰腺分泌物中达到的最大浓度分别为：3.88±1.46μg/ml（甲氨蝶呤，MTP）、6.07±4.95μg/ml（甲氧苄啶，TMP）和7.78±1.84μg/ml（四氧普明，TXP）。就血浆而言，通过计算AUC比值可知，这些药物在胰腺分泌物中的浓度是血浆中的2.72倍（MTP）、3.57倍（TMP）和4.18倍（TXP）。