Takeo S, Schraven E, Keil M, Nitz R E
Arzneimittelforschung. 1982;32(11):1412-7.
Effects of high doses of vitamin D on rat hearts were investigated 72 h after the administration of 500 000 U/kg. Histological examination showed disseminated focal necrosis with reactive round cell and granulocytic infiltration in the heart. The calcium content was increased by about 70%. These findings indicate vitamin D-induced myocardial lesions. Heart mitochondrial calcium binding and uptake activities were lower than in control animals. Na+-K+-ATPase activity of heart washed particles was reduced by the treatment with vitamin D whereas neither calcium binding and uptake activities of cardiac sarcoplasmic reticulum nor myofibrillar ATPase activity were affected. Carbocromen (20 and 100 mg/kg/d) treatment reduced vitamin D-induced decreases in mitochondrial calcium accumulating ability and Na+-K+-ATPase activity of heart washed particle, suggesting a beneficial effect of carbocromen against vitamin D-induced cardiac injury.
在给予500 000 U/kg维生素D 72小时后，研究了高剂量维生素D对大鼠心脏的影响。组织学检查显示心脏有散在的局灶性坏死，并伴有反应性圆形细胞和粒细胞浸润。钙含量增加了约70%。这些发现表明维生素D可引起心肌损伤。心脏线粒体钙结合和摄取活性低于对照动物。用维生素D处理后，心脏洗涤颗粒的Na+-K+-ATP酶活性降低，而心肌肌浆网的钙结合和摄取活性以及肌原纤维ATP酶活性均未受影响。卡波孟（20和100 mg/kg/d）处理可减轻维生素D引起的线粒体钙蓄积能力下降以及心脏洗涤颗粒的Na+-K+-ATP酶活性降低，提示卡波孟对维生素D引起的心脏损伤具有有益作用。
