大鼠不同脑区鸟氨酸脱羧酶活性的日变化
Diurnal variation in ornithine decarboxylase activity of different brain regions of the rat.
作者信息
Soliman K F, Udoye M O, Iramain C A, Walker C A
出版信息
Neurosci Lett. 1982 Dec 13;33(3):285-8. doi: 10.1016/0304-3940(82)90386-x.
The activity of ornithine decarboxylase (ODC) was studied in the brain of Sprague-Dawley male rats weighing 200-250 g. In this study, animals were maintained at a temperature of 21 +/- 1 degree C and a 12:12 h light--dark cycle for a minimum of 3 weeks prior to any experimentation. Animals were sacrificed at 06.00 h and 18.00 h and the brain cerebral cortex, hypothalamus, amygdala, hippocampus, midbrain, pons, medulla oblongata and cerebellum were isolated and assayed for ODC activity. The data show significant diurnal variations (P less than 0.05) in hypothalamus, midbrain, medulla oblongata and cerebellum, with peak values during the active phase of the animal. Other brain parts studied did not show any significant diurnal variations.
对体重200 - 250克的雄性斯普拉格 - 道利大鼠的大脑中鸟氨酸脱羧酶（ODC）的活性进行了研究。在本研究中，在进行任何实验之前，动物在21±1摄氏度的温度和12:12小时的明暗周期下饲养至少3周。在上午6点和下午6点处死动物，分离大脑的大脑皮层、下丘脑、杏仁核、海马体、中脑、脑桥、延髓和小脑，并测定ODC活性。数据显示，下丘脑、中脑、延髓和小脑存在显著的昼夜变化（P < 0.05），在动物活动期达到峰值。研究的其他脑区未显示出任何显著的昼夜变化。
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