多巴胺对催乳素的刺激控制。
Stimulatory control of prolactin by dopamine.
作者信息
Brown G M, Seggie J A
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(4-6):355-8. doi: 10.1016/s0278-5846(82)80106-1.
PMID:6891802
Abstract
- In addition to evidence that dopamine (DA) inhibits prolactin (PRL) via the tuberinfundibular system, there is also evidence for excitatory effects of DA via that system as well as evidence for regulation by DA sites lying behind the blood brain barrier. 2. Apomorphine (APO) was given to rats pretreated with either a peripheral (domperidone, DOM) or a central (haloperidol, HAL) DA blocker and prolactin responses examined. 3. Both DOM and HAL caused prolactin elevation. 4. Further elevation of prolactin was produced by APO in HAL treated animals, indicating an excitatory dopamine effect on prolactin.
摘要
- 除了多巴胺（DA）通过结节漏斗系统抑制催乳素（PRL）的证据外，还有证据表明DA通过该系统产生兴奋作用，以及血脑屏障后DA位点进行调节的证据。2. 给预先用外周（多潘立酮，DOM）或中枢（氟哌啶醇，HAL）DA阻断剂处理的大鼠注射阿扑吗啡（APO），并检测催乳素反应。3. DOM和HAL均导致催乳素升高。4. APO在HAL处理的动物中使催乳素进一步升高，表明多巴胺对催乳素具有兴奋作用。
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