Philipp K, Endler M, Neuberger M
Z Geburtshilfe Perinatol. 1982 Nov-Dec;186(6):338-41.
The effect of nicotine consumption on uteroplacental blood flow and on the carboxyhemoglobin concentration in maternal serum was examined in 20 pregnant women. It was found that poor uteroplacental circulation is more frequent in women who smoke than in those in whom placental insufficiency is suspected. Normal circulation of Type I was only recorded in gravidae smoking not more than 10 cigarettes a day. Determination of the carboxyhemoglobin concentration in the maternal serum as an indicator of the overall level of contamination by tobacco smoke revealed a significant correlation of the morning value with the placental blood flow type. The average birthweight of the newborns of smokers was 300 g lower than might have been expected. In isolated cases chronic nicotine abuse led to intra-uterine growth retardation, with no other apparent causes of placental insufficiency.
对20名孕妇研究了尼古丁摄入对子宫胎盘血流及母体血清中碳氧血红蛋白浓度的影响。结果发现，吸烟女性子宫胎盘循环不良的情况比疑似胎盘功能不全的女性更为常见。仅在每天吸烟不超过10支的孕妇中记录到I型正常循环。测定母体血清中碳氧血红蛋白浓度作为烟草烟雾总体污染水平的指标，发现早晨值与胎盘血流类型之间存在显著相关性。吸烟者新生儿的平均出生体重比预期低300克。在个别情况下，长期尼古丁滥用导致宫内生长受限，且无其他明显的胎盘功能不全原因。
