Tosi P, Norelli G A, Barni Comparini I, Luzi P, De Santi M, Sancasciani M A, Centini F, Leoncini L
G Ital Med Lav. 1982 Jul-Sep;4(4-5):175-80.
Rats were treated with HgCl2 and/or alcohol per os in a standard diet as to get a chronic intoxication. Histological and ultrastructural examination of the liver, GPT, GOT, LDH enzymatic activities, and toxicological mercury evaluation were performed. Liver cell degenerative changes with focal necrosis, and structural alteration and fibrosis were demonstrated in the group of rats treated with HgCl2. The combined administration of HgCl2 and alcohol did not result in more advanced lesions, even if steatosis could be demonstrated in the liver. An increase of the GPT, GOT and LDH enzymatic activities was demonstrated in the rats of both groups but it was higher in the rats treated with HgCl2 and alcohol combined. On the contrary, the liver and kidney mercury storage was higher in the rats treated with HgCl2 alone.
大鼠通过在标准饮食中经口给予氯化汞和/或酒精以造成慢性中毒。对肝脏进行了组织学和超微结构检查，检测了谷丙转氨酶（GPT）、谷草转氨酶（GOT）、乳酸脱氢酶（LDH）的酶活性，并进行了汞的毒理学评估。在接受氯化汞治疗的大鼠组中，出现了肝细胞变性伴局灶性坏死、结构改变和纤维化。即使在肝脏中可证实存在脂肪变性，氯化汞与酒精联合给药并未导致更严重的病变。两组大鼠的GPT、GOT和LDH酶活性均升高，但在氯化汞与酒精联合治疗的大鼠中更高。相反，单独接受氯化汞治疗的大鼠肝脏和肾脏中的汞蓄积量更高。
