Tagashira E, Matsukawa K, Urano T, Suzuki T, Yanaura S
Yakubutsu Seishin Kodo. 1982 Jul;2(1):13-24.
The purpose of the present paper is to investigate the effect of combined treatment of morphine and ethanol on preference for morphine or ethanol and morphine dependence formation. Rats were treated with morphine by DAF (drug-admixed food; 0.5 and 1 mg/g food) method or subcutaneous injection (20-100 mg/kg body weight), and/or treated with ethanol solution (5 and 10 w/w %) or oral administration (2.5 g/kg body weight). There were no effects of chronic treatment of ethanol and morphine on preference for morphine and ethanol, respectively. While, preference for morphine did not increase and preference for ethanol enhanced markedly in rats chronically treated with morphine and ethanol. Effect of chronic ethanol treatment on morphine physical dependence formation in rats was evaluated by body weight loss after morphine withdrawal, and the weight loss significantly attenuated and diarrhea was suppressed in comparison with morphine alone group. These results indicated that preference for morphine and morphine physical dependence formation were reduced when rats were chronically treated with ethanol during chronic morphine treatment, and that preference for ethanol was enhanced.
本文的目的是研究吗啡与乙醇联合治疗对吗啡或乙醇偏好以及吗啡依赖形成的影响。采用药物掺食法（DAF；0.5和1毫克/克食物）或皮下注射（20 - 100毫克/千克体重）对大鼠进行吗啡处理，和/或用乙醇溶液（5%和10% w/w）或口服给药（2.5克/千克体重）对大鼠进行乙醇处理。长期给予乙醇和吗啡分别对吗啡和乙醇偏好没有影响。然而，长期接受吗啡和乙醇治疗的大鼠对吗啡的偏好没有增加，对乙醇的偏好却显著增强。通过吗啡戒断后的体重减轻来评估长期乙醇处理对大鼠吗啡身体依赖性形成的影响，与单独使用吗啡组相比，体重减轻明显减轻，腹泻得到抑制。这些结果表明，在慢性吗啡治疗期间对大鼠进行长期乙醇处理时，对吗啡的偏好和吗啡身体依赖性形成会降低，而对乙醇的偏好会增强。
