Gisselbrecht C, Calvo F, Mignot L, Pujade E, Bouvry M, Danne O, Belpomme D, Morvan F, Marty M
Nouv Presse Med. 1982 May 22;11(24):1859-62.
Twenty-one patients with advanced, inoperable epidermoid carcinoma of the oesophagus were treated with combined 5-fluorouracil (F, 600 mg/m2, days 1 and 8), adriamycin (A, 30 mg/m2, day 1) and cis-platinum (C, 75 mg/m2, day 1), together with hydratation and mannitol-induced diuresis. Each course was repeated after 4 weeks. Response could be assessed in all 21 patients and was objective in seven (33%), who had metastasis prior to treatment. Two of these 7 patients went into complete remission confirmed by negative endoscopy and pathology; 5 showed partial response. Median survival of the 21 patients was 8 months; it fell to 4.5 months in non-responders and rose over 9 months in responders. Three patients survived for more than 16 months. No severe bone marrow depression or nephrotoxicity was observed. The 3-drug combination appeared to be more effective than the additive effects of each drug given separately. It is concluded that the FAP regimen is useful in the treatment of advanced oesophageal tumours.
21例晚期不可切除的食管表皮样癌患者接受了联合治疗，使用5-氟尿嘧啶（F，600mg/m²，第1天和第8天）、阿霉素（A，30mg/m²，第1天）和顺铂（C，75mg/m²，第1天），同时进行水化和甘露醇诱导利尿。每4周重复一个疗程。所有21例患者均可评估反应，其中7例（33%）有客观反应，这些患者在治疗前有转移。这7例患者中有2例经内镜和病理检查证实完全缓解；5例显示部分缓解。21例患者的中位生存期为8个月；无反应者降至4.5个月，有反应者升至9个月以上。3例患者存活超过16个月。未观察到严重的骨髓抑制或肾毒性。三联药物联合似乎比每种药物单独使用的相加效果更有效。结论是FAP方案对晚期食管肿瘤的治疗有用。
