Wang T Y, Erlandson R A, Marcove R C, Huvos A G
Arch Pathol Lab Med. 1980 Feb;104(2):100-4.
We describe a primary leiomyosarcoma arising in the proximal part of the right tibia of a 65-year-old man. The diagnosis was confirmed by both histochemical and electron microscopical studies. Ultrastructural examination revealed two different neoplastic cell populations. One, the type 1 cell, resembled typical mature smooth muscle cells, whereas the type 2 cells were smaller, more pleomorphic, and contained thick myofilaments in addition to the characteristic thin actin-like filaments. The tumor most likely arose from vascular smooth muscle cells, although origin from perivascular, multipotential, mesenchymal cells cannot be ruled out. Prognosis of reported cases appears to be poor if they are treated by inadequate surgical excision and irradiation but is more promising if wide excision or major amputation is performed.
我们描述了一名65岁男性右胫骨近端发生的原发性平滑肌肉瘤。组织化学和电子显微镜研究均证实了诊断。超微结构检查显示出两种不同的肿瘤细胞群。一种是1型细胞，类似于典型的成熟平滑肌细胞，而2型细胞较小，多形性更强，除了特征性的细肌动蛋白样丝外还含有粗肌丝。肿瘤很可能起源于血管平滑肌细胞，尽管不能排除起源于血管周围的多能间充质细胞。如果通过不充分的手术切除和放疗进行治疗，报道病例的预后似乎很差，但如果进行广泛切除或大截肢，则预后更有希望。
