Drenth J, Low B W, Richardson J S, Wright C S
J Biol Chem. 1980 Apr 10;255(7):2652-5.
The three-dimensional structures of the snake venom postsynaptic neurotoxins and of the domains in wheat germ agglutinin show a remarkably similar overall folding pattern, consisting of equivalently placed, but variably sized loops which are held together by four similarly positioned disulfide bonds. Furthermore, occurrence of this wheat germ agglutinin-neurotoxin domain fold is predicted not only in the snake venom cardiotoxins and cytotoxins with neurotoxin-matched half-cystine sequence positions, but also for two small plant proteins, hevein and ragweed pollen allergen Ra5, on the basis of a nearly exact match of their half-cystine, sequence positions with those of the wheat germ agglutinin domain.
蛇毒突触后神经毒素以及麦胚凝集素中各结构域的三维结构显示出极为相似的整体折叠模式，该模式由位置相当但大小各异的环组成，这些环通过四个位置相似的二硫键维系在一起。此外，基于其半胱氨酸序列位置与麦胚凝集素结构域的半胱氨酸序列位置几乎完全匹配，预计不仅在具有与神经毒素匹配的半胱氨酸序列位置的蛇毒心脏毒素和细胞毒素中会出现这种麦胚凝集素 - 神经毒素结构域折叠，在两种小的植物蛋白——橡胶素和豚草花粉过敏原Ra5中也会出现。
