Melchior D L, Scavitto F J, Steim J M
Biochemistry. 1980 Oct 14;19(21):4828-34. doi: 10.1021/bi00562a018.
The interactions of cholesterol and dipalmitoyl-phosphatidylcholine in bilayers were investigated by differential scanning dilatometry and related techniques. Dipalmitoyl-phosphatidylcholine bilayers ranging from 0 to 50 mol % cholesterol were studied over a temperature range of 0-50 degrees C. These investigations allowed construction of a three-dimensional surface with dimensions of mole fraction of cholesterol, temperature, and apparent partial specific volume. Much of the phenomenology reported for dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylcholine-cholesterol bilayers appears and can be interrelated on this surface. In addition to the thermotropic events associated with the system, two cholesterol-induced events at 17.5-20 and 29 mol % cholesterol are particularly in evidence.
通过差示扫描膨胀法及相关技术研究了胆固醇与二棕榈酰磷脂酰胆碱在双分子层中的相互作用。在0至50℃的温度范围内，对胆固醇摩尔分数为0至50%的二棕榈酰磷脂酰胆碱双分子层进行了研究。这些研究使得构建一个具有胆固醇摩尔分数、温度和表观偏比容三个维度的三维表面成为可能。许多关于二棕榈酰磷脂酰胆碱和二棕榈酰磷脂酰胆碱 - 胆固醇双分子层报道的现象学在这个表面上出现并且可以相互关联。除了与该系统相关的热致事件外，在胆固醇含量为17.5 - 20%和29%时的两个胆固醇诱导事件尤为明显。
