新生儿格雷夫斯病中的促甲状腺素受体刺激性抗体
Thyroid-stimulating immunoglobulins in neonatal Graves's disease.
作者信息
Teng C S, Tong T C, Hutchison J H, Yeung R T
出版信息
Arch Dis Child. 1980 Nov;55(11):894-5. doi: 10.1136/adc.55.11.894.
Abstract
Two patients with neonatal Graves's disease are reported. One of them had a delayed onset because of suppression of the fetal thyroid gland by antithyroid drug taken by the mother during pregnancy. Thyroid-stimulating immunoglobulins (TSAb), measured by a receptor assay, were present in both babies when they were thyrotoxic, and also in their mothers. TSAb were undetectable in both babies 1 year after birth. This strongly supports a pathogenetic role of TSAb in this condition through transplacental transfer of maternal TSAb.
摘要
本文报告了两例新生儿格雷夫斯病患者。其中一例发病延迟，原因是母亲在孕期服用抗甲状腺药物抑制了胎儿甲状腺。通过受体分析测定，两名婴儿在发生甲状腺毒症时均存在甲状腺刺激免疫球蛋白（TSAb），其母亲体内也有。两名婴儿在出生1年后均检测不到TSAb。这有力地支持了TSAb通过母体TSAb经胎盘转移在该病发病机制中所起的作用。
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本文引用的文献
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Changes in thyroid-stimulating antibody activity in Graves' disease treated with antithyroid drug and its relationship to relapse: a prospective study.抗甲状腺药物治疗Graves病时促甲状腺素抗体活性的变化及其与复发的关系：一项前瞻性研究。
J Clin Endocrinol Metab. 1980 Jan;50(1):144-7. doi: 10.1210/jcem-50-1-144.
2
Thyroid-stimulating immunoglobulins in Graves' disease.格雷夫斯病中的促甲状腺素受体抗体
Lancet. 1974 Aug 24;2(7878):427-31. doi: 10.1016/s0140-6736(74)91815-7.
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Placental transmission of thyroid-stimulating immunoglobulins.促甲状腺素受体刺激性抗体的胎盘传递。
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