Does basic aluminum sucrose sulfate affect blood coagulability?

Basic aluminum sucrose sulfate (sucralfate) is a sulfated disaccharide similar in structure to heparin that has been shown not to possess anticoagulant effects in vitro or in animal models. As an adjunct to a study of the efficacy of sucralfate in the treatment of duodenal ulcer disease, we evaluated the drug's anticoagulant effects. Twenty-eight patients were randimized to treatment with sucralfate. Evaluations of prothrombin time and activated partial thromboplastin time, prestudy and after two and/or four weeks of treatment with sucralfate, demonstrated no evidence of anticoagulant activity.