Tomashefski J F, Hirsch C S, Jolly P N
Arch Pathol Lab Med. 1981 Feb;105(2):89-93.
Four persons had extensive pulmonary granulomatosis from intravenous injections of cellulose derived from tablets intended for oral consumption. Three of these persons were known abusers of pentazocine (Talwin). The principal vascular lesion induced by cellulose is thrombosis. Destruction of arterial elastic laminae and pulmonary vascular dilation commonly ensue. Two of the victims had cor pulmonale. The cellulose crystals induced foreign body granulomas when extravasated subcutaneously at injection sites on the arms, as well as in the right ventricular endocardium. Cellulose crystals have highly characteristic morphology and histochemical staining reactions that facilitate their recognition and their distinction from talc and starch. The latter substances also are used as fillers in tablets and capsules, and lodge in the pulmonary vessels of persons who inject them intravenously.
有四人因静脉注射口服片剂中提取的纤维素而患上广泛的肺部肉芽肿病。其中三人是已知的喷他佐辛（镇痛新）滥用者。纤维素引发的主要血管病变是血栓形成。随后通常会出现动脉弹性膜破坏和肺血管扩张。两名受害者患有肺心病。纤维素晶体在手臂注射部位皮下外渗时，以及在右心室心内膜中，会引发异物肉芽肿。纤维素晶体具有高度特征性的形态和组织化学染色反应，便于识别以及与滑石粉和淀粉区分开来。后两种物质也用作片剂和胶囊中的填充剂，并会在静脉注射者的肺血管中沉积。
