小鼠鞘内注射吗啡：一项新技术。
Intrathecal morphine in mice: a new technique.
作者信息
Hylden J L, Wilcox G L
出版信息
Eur J Pharmacol. 1980 Oct 17;67(2-3):313-6. doi: 10.1016/0014-2999(80)90515-4.
PMID:6893963
Abstract
A simple, rapid technique for intrathecal injections by lumbar puncture in unanesthetized mice is described. Intrathecal [3H]morphine base was not found in significant quantities in either the midbrain or forebrain. Submicrogram quantities of morphine sulfate induced Straub tail response and tail-flick analgesia. These effects were dose related and antagonized by subcutaneous naloxone.
摘要
描述了一种在未麻醉小鼠中通过腰椎穿刺进行鞘内注射的简单、快速技术。在中脑或前脑中均未发现大量的鞘内[3H]吗啡碱。微克量的硫酸吗啡可诱导斯特劳布尾反应和甩尾镇痛。这些效应与剂量相关，并可被皮下注射纳洛酮拮抗。
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