Passath A, Leb G
Nuklearmedizin. 1980 Jul;19(3):127-39.
75 Patients were examined with 99mTc-BIDA in order to find a reliable method of differentiating between obstructive and parenchymatous jaundice. Serial scans, repeated recordings of plasma radioactivity and external measurements over a temporal and a thigh region were taken between 1 and 30 min after injection. Serum half life of radioactivity, extraction coefficient and clearance rate, calculated from the first exponential slope over the temporal region curve, differed significantly in obstructive as compared to parenchymatous diseases and normals. In patients with extrahepatic obstruction the curves over the temporal and the thigh region differed; within the first 30 min the thigh values tend to increase. Clearance and extraction coefficients calculated from the third exponential slope of the plasma curve were significantly lower in obstructive jaundice than in other groups, although the great variation in these values did not allow a reliable differentiation in every patient. However, reliable results were obtained when these parameters were considered together with serial hepatic images.
为了找到一种区分梗阻性黄疸和实质性黄疸的可靠方法，对75例患者进行了99mTc-BIDA检查。在注射后1至30分钟内进行了系列扫描、血浆放射性的重复记录以及颞部和大腿区域的外部测量。根据颞部区域曲线的第一个指数斜率计算出的放射性血清半衰期、提取系数和清除率，与实质性疾病和正常情况相比，梗阻性疾病有显著差异。肝外梗阻患者的颞部和大腿区域曲线不同；在前30分钟内，大腿值趋于升高。尽管这些值的巨大差异不允许对每个患者进行可靠的区分，但从血浆曲线的第三个指数斜率计算出的清除率和提取系数在梗阻性黄疸中明显低于其他组。然而，当将这些参数与系列肝脏图像一起考虑时，获得了可靠的结果。
