Bernadt M W, Silverstone T, Singleton W
Br J Psychiatry. 1980 Nov;137:452-7. doi: 10.1192/bjp.137.5.452.
It has been suggested that reversal of stress-induced tachycardia by beta-adrenergic blockade might be of benefit in the treatment of phobias. This was tested in a double-blind cross-over trial by exposing 22 female volunteers with spider or snake phobias to their phobic object 1 1/2 hours after administration of either tolamolol 200 mg, diazepam 10 mg or placebo. Although tolamolol abolished the stress-induced tachycardia, it had no beneficial behavioural or subjective effects. In contrast, diazepam, which had no significant effect on heart rate, improved behavioural performance. Subjective measures were more influenced by order effect than by medication.
有人提出，通过β-肾上腺素能阻滞剂逆转应激性心动过速可能对恐惧症的治疗有益。在一项双盲交叉试验中对此进行了测试，该试验让22名患有蜘蛛或蛇恐惧症的女性志愿者在服用200毫克托拉洛尔、10毫克地西泮或安慰剂1个半小时后接触其恐惧对象。虽然托拉洛尔消除了应激性心动过速，但它没有产生有益的行为或主观效果。相比之下，对地西泮对心率没有显著影响，但改善了行为表现。主观测量受顺序效应的影响大于药物的影响。
