Fritz K E, Augustyn J M, Jarmolych J, Daoud A S
Arch Pathol Lab Med. 1981 May;105(5):240-6.
Severe, complicated atherosclerotic lesions of swine abdominal aortas were induced by combination of balloon injury and atherogenic (HC) diet. After a reference group was killed at six months, the remaining animals were fed a mash diet for six weeks, five months, or 14 months. Extensive biochemical studies of lesions and nonlesion areas of aortas from HC diet-fed swine, and nonlesion aortic tissue from mash-fed animals emphasize the following points. Nonlesion tissues from either mash or HC diet-fed animals were remarkably similar in all features studied, and did not change much over a period of at least 20 months. Lesions differed from the adjacent nonlesion tissue in most aspects; the HC nonlesion tissue does not appear to be an intermediate in lesion development. The lesions were dynamic, changing generally in the direction of normalcy, from relatively active to more quiescent. Lesion changes did not appear immediately after institution of the regression regimen; some were delayed several months. When changes did occur, in general they were not linear with time. Whether a complete return to normalcy would result from a longer regression period needs further investigation.
通过球囊损伤和致动脉粥样硬化（HC）饮食相结合的方法，诱导猪腹主动脉出现严重、复杂的动脉粥样硬化病变。在一个参考组于6个月时处死之后，其余动物分别喂以混合饲料6周、5个月或14个月。对喂食HC饮食的猪的主动脉病变区和非病变区以及喂食混合饲料的动物的非病变主动脉组织进行的广泛生化研究强调了以下几点。喂食混合饲料或HC饮食的动物的非病变组织在所有研究特征方面都非常相似，并且在至少20个月的时间内变化不大。病变在大多数方面与相邻的非病变组织不同；HC非病变组织似乎不是病变发展的中间阶段。病变是动态的，总体上朝着正常方向变化，从相对活跃变为更静止。在开始回归方案后，病变变化并非立即出现；有些延迟了几个月。当变化确实发生时，总体上它们与时间不是线性关系。更长的回归期是否会导致完全恢复正常仍需进一步研究。
