Blair L S, Campbell W C
Parasite Immunol. 1981 Summer;3(2):143-7. doi: 10.1111/j.1365-3024.1981.tb00392.x.
Ferrets were exposed to two successive inoculations with 30 third-stage larvae of the canine heartworm Dirofilaria immitis, the inoculations being approximately 5 months apart. Each infection was terminated by ivermectin therapy approximately 2 months after inoculation. The ferrets were challenged with 30 larvae 3 weeks after the termination of the second infection, and were necropsied approximately 6 months after challenge. Of the four ferrets that survived this protracted experimentation, two were entirely free of heartworm while the other two had only a single female worm each. In contrast, 14 control ferrets that had not been immunized (four of which had been given ivermectin doses) were all infected at necropsy, yielding a mean of 6.6 worms per ferret.
雪貂连续两次接种30条犬心丝虫（恶丝虫）的第三期幼虫，两次接种间隔约5个月。每次感染在接种后约2个月通过伊维菌素治疗终止。在第二次感染终止后3周，雪貂用30条幼虫进行攻击，并在攻击后约6个月进行尸检。在经历了这场旷日持久实验的4只存活雪貂中，2只完全没有心丝虫，而另外2只每只只有1条雌虫。相比之下，14只未免疫的对照雪貂（其中4只已给予伊维菌素剂量）在尸检时均被感染，每只雪貂平均有6.6条虫。
