Matthias F R
Haemostasis. 1978;7(5):273-81. doi: 10.1159/000214269.
Following myocardial infarction, soluble fibrin in plasma is often elevated as a sign of an activated plasmatic coagulation system. Soluble fibrin in plasma is most pronounced in shock patients under catecholamine administration. With the improvement of the clinical situation the fibrin concentration declines to normal. Following incubation with N-ethylmaleimide an increased production of prostaglandin endoperoxides is observed in the platelets of patients after myocardial infarction compared to normal platelets. Plasma of patients exhibits an endoperoxide-producing effect on normal platelets. The stimulating effect of patient plasma diminishes together with the fall of soluble plasma fibrin. These phenomena may be considered as signs of a relation between the plasmatic and thrombocytic coagulation system.
心肌梗死后，血浆中可溶性纤维蛋白常升高，这是血浆凝血系统激活的标志。在接受儿茶酚胺治疗的休克患者中，血浆可溶性纤维蛋白最为明显。随着临床状况的改善，纤维蛋白浓度降至正常。与正常血小板相比，用N-乙基马来酰亚胺孵育后，心肌梗死患者血小板中前列腺素内过氧化物的产生增加。患者血浆对正常血小板具有产生内过氧化物的作用。患者血浆的刺激作用随着血浆可溶性纤维蛋白的下降而减弱。这些现象可被视为血浆凝血系统和血小板凝血系统之间存在关联的标志。
