Löbe L P, Katenkamp D
Laryngol Rhinol Otol (Stuttg). 1981 Jun;60(6):334-7.
From 1950 to 1979 276 malignant tumors of nasal cavity and paranasal sinuses were treated in the Clinic of Oto-Rhino-Laryngology of the University. 40 cases (14,5% of these tumors) were diagnosed as malignant non-Hodgkin's lymphoma, 18 cases of them could be classified according to the so-called Kiel classification. There were 11 highly malignant lymphomas (including 7 immunoblastic lymphomas) and 7 low malignant (immunocytic) lymphomas. Basing on the histologic types of lymphomas and the predominant localization in the inner nose and the anterior ethmoidal sinus a pathogenetic importance of a chronic immunologic inflammation for the development of the lymphomas is suggested. Highly malignant immunoblastic lymphomas have a poor prognosis, almost all tumors generalize and lead to death within one year. Therefore, after the initial staging procedure, after the primary therapeutic irradiation and the following operation a polychemotherapy must be performed. The prognosis of immunocytic lymphomas is somewhat better, they generalize more seldom than highly malignant lymph node tumors. From the findings presented here the conclusion can be drawn that in the region of nasal cavity and paranasal sinuses the regional lymphatic spread of lymphomas is of little importance only.
1950年至1979年间，该大学耳鼻咽喉科诊治了276例鼻腔及鼻窦恶性肿瘤。其中40例（占这些肿瘤的14.5%）被诊断为恶性非霍奇金淋巴瘤，其中18例可根据所谓的基尔分类法进行分类。有11例高度恶性淋巴瘤（包括7例免疫母细胞性淋巴瘤）和7例低度恶性（免疫细胞性）淋巴瘤。基于淋巴瘤的组织学类型以及在内鼻和筛窦前部的主要定位，提示慢性免疫炎症在淋巴瘤发生中具有致病重要性。高度恶性的免疫母细胞性淋巴瘤预后较差，几乎所有肿瘤都会扩散，患者会在一年内死亡。因此，在初始分期程序、初次治疗性放疗及后续手术后，必须进行多药化疗。免疫细胞性淋巴瘤的预后稍好一些，它们比高度恶性淋巴瘤更不易扩散。从这里呈现的研究结果可以得出结论，在鼻腔及鼻窦区域，淋巴瘤的区域淋巴扩散仅具有很小的重要性。
