生长激素与1,25 - 二羟维生素D3在肠道钙转运中的关系。

The relationship of growth hormone to 1,25-dihydroxyvitamin D3 in intestinal calcium transport.

作者信息

Yeh J K, Aloia J F

出版信息

Metab Bone Dis Relat Res. 1981;3(1):47-9. doi: 10.1016/s0221-8747(81)80023-9.

Abstract

The effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) and bovine growth hormone (bGH) on intestinal calcium transport have been assessed in vitamin D deficient rats. Calcium transport did not increase after 7 days bGH treatment. A single dose of 1,25(OH)2D3 significantly increased calcium transport in the hypophysectomized (Hx) rats treated with bGH but not in the Hx rats who did not receive bGH, unless the dosage of 2,25(OH)2D3 was increased to 500 p moles. Even though calcium transport in the Hx rats was stimulated by the high dose of 1,25(OH)2D3, this response was less in the Hx than in bGh treated group. These results suggest that growth hormone status may be important in the expression of 1,25-(OH)2D3 action on intestinal calcium transport.

摘要

在维生素D缺乏的大鼠中评估了1,25 - 二羟基维生素D3（1,25(OH)2D3）和牛生长激素（bGH）对肠道钙转运的影响。bGH治疗7天后钙转运未增加。单剂量的1,25(OH)2D3显著增加了接受bGH治疗的垂体切除（Hx）大鼠的钙转运，但在未接受bGH的Hx大鼠中未增加，除非将1,25(OH)2D3的剂量增加到500皮摩尔。尽管高剂量的1,25(OH)2D3刺激了Hx大鼠的钙转运，但Hx大鼠的这种反应比bGH治疗组要小。这些结果表明，生长激素状态可能在1,25-(OH)2D3对肠道钙转运的作用表达中起重要作用。