Khachadurian A K
Am Fam Physician. 1981 Dec;24(6):143-8.
Gout may be a primary or a secondary disorder. In both types of gout, overproduction or underexcretion of uric acid, or a combination of these abnormalities, may be the underlying mechanism. Controversy exists over the need for treatment of asymptomatic hyperuricemia. Treatment of tophi requires use of both uricosurics and allopurinol. A xanthine oxidase inhibitor is the drug of choice for patients with uric acid stones and for those with renal insufficiency.
痛风可能是原发性或继发性疾病。在这两种类型的痛风中，尿酸生成过多或排泄过少，或这些异常情况的组合，可能是潜在机制。对于无症状高尿酸血症是否需要治疗存在争议。痛风石的治疗需要同时使用促尿酸排泄药和别嘌醇。黄嘌呤氧化酶抑制剂是尿酸结石患者和肾功能不全患者的首选药物。
